Fig. 4.
Maximal vasorelaxation (A) and timeline for PPT (B) and DPN (C) during the vasodilatory phase of hypoxia. Force is expressed as %change from PE-precontraction. PPT and DPN in the highest concentrations enhanced vasorelaxation during hypoxia similar to E2. However, this effect was not different from vehicle. N = 4–10/group. A: †P < 0.001 for PPT 5 × 10−5 M, E2 and vehicle vs. control; #P < 0.01 for DPN 5 × 10−5 M vs. control. B: *P < 0.05 for PPT 5 × 10−5 M vs. control; ##P < 0.05 for E2 vs. control; ††P < 0.05 for vehicle vs. control. C: ‡P < 0.001 for DPN 5 × 10−5 M, E2, and vehicle vs. control.