Fig. 5.
Maximal phase II HPV (A) and timeline for PPT (B) and DPN (C) during HPV. Force is expressed as %change from PE-precontraction. While PPT (10−6 M and 5 × 10−5 M) decreased HPV compared with control, this effect was not different from vehicle. In contrast, DPN (5 × 10−5 M) significantly and rapidly (<25 min after induction of hypoxia) decreased HPV compared with vehicle and control. N = 4–10/group. A: *P < 0.05 vs. control; #P < 0.01 vs. control; ‡P < 0.0001 vs. control; †P < 0.01 vs. vehicle, E2 and PPT 10−6 M. B: ††P < 0.05 for PPT 5 × 10−5 M vs. control. (C) **P < 0.001 for DPN 5 × 10−5 M and E2 vs. control; ##P < 0.05, ###P < 0.001 for DPN 5 × 10−5 M vs. vehicle.