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. Author manuscript; available in PMC: 2009 Oct 28.
Published in final edited form as: Neuroscience. 2008 Aug 27;156(4):872–884. doi: 10.1016/j.neuroscience.2008.08.042

Fig. 2.

Fig. 2

The selective PKCζ pseudosubstrate peptide inhibitor ZIP attenuates CR acquisition and expression, as does the PI3-kinase inhibitor wortmannin. (A) Physiological records of abducens nerve recordings prior to and during application of ZIP (5 μM) show suppressed expression of CRs (arrows) during early application. (B) Acquisition curves (means ± SD) show that ZIP significantly attenuated CR acquisition (left panel) and expression (right panel). However, the effect of ZIP on CR expression was reversed after prolonged exposure to the drug. (C) Bath application of wortmannin (200 nM; Wortm) also severly attenuated the acquisition and expression of CRs. * indicate significant differences from session 2. P values are given in the text.