Fig. 2.
Effect of chronic hypoxia on PKG protein expression and activity in pulmonary veins of fetal lambs. Left: Western blots and densitometric scanning of PKG protein normalized to actin. Right: PKG activity at basal conditions and stimulated with cGMP (3 × 10−6 M) of pulmonary veins of normoxic and chronically hypoxic fetal lambs. PKG-I, Rp-8-Br-PET-cGMPS (3 × 10−5 M). Data are shown as means ± SE; n = 6 -8 for each group. *Significantly different from normoxic vessels. †Significantly different from basal (P < 0.05).