Fig. 1.
Effect of transgenic mouse strain on the nasal potential difference (NPD) response to lubiprostone (Lubi). The standard NPD protocol was modified to replace the isoproterenol perfusion with a dose escalation of lubiprostone. Data are expressed as mean millivolts of potential difference (y-axis) in each perfusate (x-axis). Error bars mark the SD. CFTRtm1Unc-Tg(FABPCFTR)1Jaw/J, gut corrected bitransgenic (CFKO), n = 12; C57Bl/6, n = 12; A/J, n = 8. The A/J and CFKO strains have nearly identical lubiprostone responses.