Fig. 3.
Rate of plasma membrane Ca2+ extrusion is unchanged in PASMCs with maturation. Representative [Ca2+]i recordings from myocytes of fetal (A) and adult (B) sheep show effect of extracellular Ca2+ removal in the presence of 10 μM CPA upon depletion of sarcoplasmic reticulum (SR) Ca2+ stores using the protocol described in Fig. 2. Solid curves show exponential curve-fit analyses. C: average plasma membrane clearance rate constant (mclear) for cells from fetal and adult sheep. Values are means ± SE. No significant difference was observed (P = 0.37 by unpaired t-test).