Fig. 7.
Serotonin (5-HT)-mediated Ca2+ signaling increases with maturation in PASMCs. Representative traces show 5-HT-mediated [Ca2+]i elevation in myocytes from fetal (A) and adult (B) sheep. C: percentage of PASMCs from fetal and adult sheep showing Ca2+ elevation in response to 10 μM 5-HT. Responses of 78 cells from fetal and 43 cells from adult sheep were recorded. D: average increase in [Ca2+]i due to 10 μM 5-HT in cells from fetal and adult sheep. Values are means ± SE. No significant difference was observed (P = 0.6 by unpaired t-test). *P < 0.001 (by χ2 test).