Fig. 4.

Formalin-fixed lung sections from challenged mice ± drug treatment were stained with hematoxylin and eosin (H&E) or periodic acid-Schiff (PAS) as described in materials and methods. A: H&E sections under ×100 power showing perivascular and parenchymal inflammation (bottom left represents a × 400 magnification of the delineated area above). Right panels represent 2 independent sections from lungs treated with Compound A, as described in materials and methods. B: alcian blue/PAS staining for assessment of mucus production. The illustrations are representative of multiple experiments and depict the overall changes observed with treatment of allergic mice with compound A.