Fig. 2.

cAMP response element binding protein (CREB) phosphorylation in CF mouse nasal epithelium (MNE) and cell models. A: representative gel and densitometry data of phosphorylated CREB (pCREB)/total CREB ratio in MNE from WT and Cftr^−/− mice (n = 6 for each condition). Error bars represent SE, and significance was determined by t-test (*P < 0.01). B: representative gel and densitometry data of pCREB/total CREB ratio in 9/HTEo- WT (pCEP) and CF model (pCEPR) cells (n = 3 for each condition). Error bars represent SE, and significance was determined by t-test (*P < 0.001).