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Effect of macrophage depletion on CXCL1 (KC). To determine whether macrophages are the source of CXCL1 in ischemic AKI, we measured CXCL1 in the kidney in macrophage-depleted mice using 2 bead-based multiplex cytokine kits. The increase in CXCL1 in ischemic AKI was virtually completely inhibited by macrophage depletion with liposomal encapsulated clodronate (LEC). *P < 0.01 vs. sham. **P < 0.05 vs. AKI + vehicle (empty liposomes).
