Fig. 4.

SS-31 decreases macrophage expression in a 14-day UUO model. Animals were pretreated with SS-31 1 day before UUO and daily for 14 days. Control animals received saline only throughout the period of UUO. Macrophages were visualized by immunoperoxidase for ED-1 (see materials and methods). Control CK, control OK, and SS-31-treated OK (1 mg/kg) are shown, as in Fig. 1. Representative macrophages are shown by arrows, and counts of macrophages are shown on the right.