Table 1.
Fold-increase in mRNA expression of various genes in the obstructed kidney
| CLK | OK | CLK-SS-31 | OK-SS-31 | |
|---|---|---|---|---|
| Caspase-3 | 1.0±0.1 | 9.6±1.4* | 1.0±0.1 | 5.4±1.3† |
| HO-1 | 1.0±0.1 | 17.9±7.9* | 1.0±0.1 | 6.9±2.9† |
| CCR-1 | 1.0±0 | 4.7±1.3* | 1.0±0.1 | 5.12±1.5 |
| P38-MAPK | 1.0±0.1 | 3.6±0.5* | 1.0±0 | 2.9±0.7† |
Values (means ± SE) listed are CT2ΔΔ for the obstructed kidney (OK) compared with the contralateral kidney (CLK) set as 1.0. Real-time PCR was carried out as in materials and methods. HO, heme oxygenase. SS-31 are kidneys treated with 1 mg/kg SS-31 for 14 days.
*
P < 0.05 compared with CLK.
†
P < 0.05 compared with untreated OK.