Table 7.
DN transport with furosemide: maneuvers to enhance urine acidification
HCO3− | TA | NH4+ | Net Acid | Urine pH | |
---|---|---|---|---|---|
Absolute excretion, μmol/min | |||||
HCO3− = 4 mM (Table 6) | 0.37 | 0.49 | 0.97 | 1.09 | 6.23 |
HCO3− = 2 mM | 0.36 | 0.50 | 0.99 | 1.12 | 6.22 |
Phosphate = 8 mM | 0.32 | 1.02 | 0.99 | 1.68 | 6.16 |
Principal cell × 2 | 0.34 | 0.47 | 0.92 | 1.06 | 6.27 |
β-Cell × 10% | 0.04 | 0.63 | 1.05 | 1.64 | 5.47 |
α-Cell × 2 | 0.13 | 0.58 | 1.24 | 1.68 | 5.88 |
Principal and α × 2 | 0.12 | 0.57 | 1.19 | 1.64 | 5.90 |
α-Cell × 3 | 0.02 | 0.65 | 1.50 | 2.13 | 5.15 |
Absolute reabsorption, μmol/min | |||||
HCO3− = 4 mM (Table 6) | 0.49 | −0.10 | −0.29 | 0.88 | |
HCO3− = 2 mM | 0.07 | 0.01 | −0.30 | 0.36 | |
Phosphate = 8 mM | 0.54 | −0.24 | −0.30 | 1.08 | |
Principal cell × 2 | 0.53 | −0.08 | −0.24 | 0.85 | |
β-Cell × 10% | 0.82 | −0.24 | −0.37 | 1.43 | |
α-Cell × 2 | 0.73 | −0.19 | −0.55 | 1.47 | |
Principal and α × 2 | 0.75 | −0.18 | −0.50 | 1.43 | |
α-Cell × 3 | 0.85 | −0.26 | −0.81 | 1.92 |