Figure 6.

Curcumin prevents necrosis and inflammation of pancreatic tissue on multiple low doses of streptozotocin (MLD-STZ) exposure. Data are representative of three independent experiments. At least 10 different mice were screened for each group. (a) Pancreatic sections from untreated animal. In (b), a necrosed pancreatic section from an MLD-STZ-treated mouse is shown; the arrowhead indicates a necrosed islet of Langerhans. (c) Pancreas of curcumin-treated control mice. In (d), a pancreatic section of mice treated with curcumin prior to MLD-STZ exposure (CUR+MLD-STZ), devoid of necrosis and inflammation, is shown.