Figure 2.

Antinociceptive effect of vehicle (10% dimethylsulphoxide in 0.9% NaCl) or five test compounds alone or in combination with rimonabant (rimonab), or AM251 or AM630 in the formalin test in mice. Numbers after the names of the compounds indicate the doses (i.p.) used for each experiment. Each point represents the mean±s.e.mean of 8–10 animals per group. Data were analysed using one-way ANOVA followed by Bonferroni's test and statistical significance was taken as P<0.05. Circles denote statistically significant differences from the data obtained with a given compound in the absence of antagonists and, in the case of panel f refer to both rimonabant and AM630. (a) Effect of rimonabant (2.5 mg kg⁻¹) on OMDM 119 and OMDM 122 (5 mg kg⁻¹); (b) Effect of AM251 (1 and 3 mg kg⁻¹) on OMDM 119 (5 mg kg⁻¹); (c) Effect of rimonabant (1 mg kg⁻¹) on OMDM 133 (1 mg kg⁻¹); (d) Effect of AM251 (3 mg kg⁻¹) on OMDM 133 (2.5 and 5 mg kg⁻¹); (e) Effect of rimonabant (1 mg kg⁻¹) on LY2183240 (2.5 mg kg⁻¹); (f) Effect of rimonabant (1 mg kg⁻¹) or AM630 (1 mg kg⁻¹) on OMDM 132 (5 mg kg⁻¹).