Table 1.
The summary of single-channel kinetic analysis of the OT distributions from the wild-type receptor under control conditions and in the presence of fipronil
| Agonist, modulator | OT1 (ms) | Fraction OT1 | OT2 (ms) | Fraction OT2 | OT3 (ms) | Fraction OT3 | N |
|---|---|---|---|---|---|---|---|
| 50 μM GABA | 0.32±0.17 | 0.25±0.04 | 2.5±0.9 | 0.58±0.08 | 7.8±2.3 | 0.17±0.11 | 3 |
| 50 μM GABA+10 μM fipronil | 0.26±0.12 | 0.35±0.09 | 2.3±0.8 | 0.42±0.11 | 6.5±1.3 | 0.23±0.09 | 4 |
| 1 mM GABA | 0.53±0.13 | 0.16±0.11 | 2.6±1.2 | 0.68±0.07 | 7.3±3.6 | 0.16±0.07 | 4 |
| 1 mM GABA+10 μM fipronil | 0.38±0.10 | 0.26±0.06 | 2.0±0.4 | 0.60±0.06 | 6.6±1.5 | 0.14±0.11 | 5 |
Abbreviation: OT, open time.
The intracluster OT histograms were fitted to a sum of three exponentials. The table gives the mean durations (OT1–3) and relative contributions (fraction OT1–3) for the three OT components. The presence of fipronil did not lead to statistically significant changes in the OT distributions (P>0.05; Student's t-test).