Table 2. Relationship between PKCδ expression and characteristics of the breast carcinomas.
|
mRNA (PCR)
|
Protein (western blot)
|
Protein (ELISA)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
78 kDa isoform
|
160 kDa isoform
|
||||||||||
| Tumour characteristics | n | Median | P-value | n | Median | P-value | Median | P-value | n | Median | P-value |
| Size (cm) | |||||||||||
| ⩽2 | 53 | 1.75 | 0.406* | 20 | 0.0288 | 0.139* | 0.2155 | 0.989* | 20 | 10.56 | 0.635* |
| >2–5 | 127 | 2.04 | 62 | 0.0896 | 0.2051 | 62 | 12.49 | ||||
| >5 | 15 | 1.43 | 8 | 0.0367 | 0.2576 | 8 | 8.48 | ||||
| Grade | |||||||||||
| 1 and 2 | 98 | 2.13 | 0.613 | 38 | 0.0315 | 0.016 | 0.2024 | 0.883 | 38 | 7.88 | 0.243 |
| 3 | 100 | 1.8 | 54 | 0.1003 | 0.1968 | 57 | 12.80 | ||||
| Nodal status | |||||||||||
| Negative | 87 | 1.98 | 0.874 | 43 | 0.0991 | 0.401 | 0.1555 | 0.290 | 41 | 11.68 | 0.580 |
| Positive | 109 | 1.89 | 48 | 0.0663 | 0.2981 | 53 | 9.57 | ||||
| ER | |||||||||||
| Negative | 51 | 1.34 | 0.007 | 24 | 0.0836 | 0.349 | 0.1369 | 0.030 | 24 | 14.30 | 0.977 |
| Positive | 151 | 2.28 | 69 | 0.0626 | 0.3236 | 73 | 9.57 | ||||
| Age | |||||||||||
| ⩽50 | 65 | 1.97 | 0.029 | 24 | 0.0744 | 0.767 | 0.2335 | 0.900 | 28 | 7.82 | 0.392 |
| >50 | 143 | 2.54 | 70 | 0.0685 | 0.2 | 70 | 11.45 | ||||
| Histological type | |||||||||||
| Ductal | 173 | 1.88 | 0.250* | 83 | 0.0742 | 0.889* | 0.2104 | 0.891* | 86 | 9.71 | 0.336* |
| Lobular | 19 | 2.15 | 6 | 0.1447 | 0.0917 | 7 | 20.87 | ||||
| Ductal and lobular | 11 | 2.89 | 3 | 0.062 | 0.1792 | 3 | 26.88 | ||||
ER=oestrogen receptor; PKC=protein kinase C.
P-values were determined by either the Mann–Whitney U-test or Kruskall–Wallis test*.