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. 2008 Oct 28;99(10):1644–1650. doi: 10.1038/sj.bjc.6604728

Table 2. Relationship between PKCδ expression and characteristics of the breast carcinomas.

  mRNA (PCR)
Protein (western blot)
Protein (ELISA)
        78 kDa isoform
160 kDa isoform
     
Tumour characteristics n Median P-value n Median P-value Median P-value n Median P-value
Size (cm)
 ⩽2 53 1.75 0.406* 20 0.0288 0.139* 0.2155 0.989* 20 10.56 0.635*
 >2–5 127 2.04   62 0.0896   0.2051   62 12.49  
 >5 15 1.43   8 0.0367   0.2576   8 8.48  
                       
Grade
 1 and 2 98 2.13 0.613 38 0.0315 0.016 0.2024 0.883 38 7.88 0.243
 3 100 1.8   54 0.1003   0.1968   57 12.80  
                       
Nodal status
 Negative 87 1.98 0.874 43 0.0991 0.401 0.1555 0.290 41 11.68 0.580
 Positive 109 1.89   48 0.0663   0.2981   53 9.57  
                       
ER
 Negative 51 1.34 0.007 24 0.0836 0.349 0.1369 0.030 24 14.30 0.977
 Positive 151 2.28   69 0.0626   0.3236   73 9.57  
                       
Age
 ⩽50 65 1.97 0.029 24 0.0744 0.767 0.2335 0.900 28 7.82 0.392
 >50 143 2.54   70 0.0685   0.2   70 11.45  
                       
Histological type
 Ductal 173 1.88 0.250* 83 0.0742 0.889* 0.2104 0.891* 86 9.71 0.336*
 Lobular 19 2.15   6 0.1447   0.0917   7 20.87  
 Ductal and lobular 11 2.89   3 0.062   0.1792   3 26.88  

ER=oestrogen receptor; PKC=protein kinase C.

P-values were determined by either the Mann–Whitney U-test or Kruskall–Wallis test*.