Table 5. Univariate and multivariate cox proportional hazards models for the predictors of overall survival (results from mean value cutoffs).

	Univariate analysis			Multivariate analysis a
Variables	HR	95% CI	P-value	HR	95% CI	P-value
CD3b	0.627	0.410–0.627	0.031	0.813	0.523–1.264	0.358
CD8b	0.583	0.358–0.950	0.030	0.574	0.347–0.949	0.031
CD45ROb	0.530	0.331–0.850	0.008	0.612	0.377–0.995	0.048
CD3CD8c	0.522	0.303–0.900	0.019	0.572	0.325–1.010	0.054
CD3CD45ROc	0.441	0.252–0.772	0.004	0.565	0.317–1.009	0.054
CD8CD45ROc	0.416	0.221–0.785	0.007	0.436	0.227–0.838	0.013
CD3CD8CD45ROd	0.393	0.202–0.766	0.006	0.471	0.236–0.937	0.032

CI=confidence interval; HR=hazard ratio.

The results were according to the density groups of TIL with mean value cutoffs.

Univariate and multivariate Cox proportional hazards models were used as statistical methods.

^aTumour stage (T stage), histologic classification (WHO), presence of lymph node metastasis, and presence of lymphatic invasion which were proved to have a prognostic significance in univariate analysis were adopted as covariates in each multivariate analysis.

^bHigh vs low.

^cHigh/high vs low/low.

^dHigh/high/high vs low/low/low.