Table 6. Univariate and multivariate cox proportional hazard models for the predictors of overall survival (results from 75th percentile cutoffs).

	Univariate analysis			Multivariate analysis a
Variables	HR	95% CI	P-value	HR	95% CI	P-value
CD3b	0.446	0.261–0.760	0.003	0.549	0.317–0.951	0.032
CD8b	0.583	0.358–0.950	0.030	0.574	0.347–0.949	0.031
CD45ROb	0.483	0.287–0.813	0.006	0.507	0.298–0.862	0.012
CD3CD8c	0.373	0.193–0.721	0.003	0.403	0.205–0.795	0.009
CD3CD45ROc	0.305	0.147–0.632	0.001	0.337	0.161–0.708	0.004
CD8CD45ROc	0.418	0.216–0.809	0.010	0.413	0.211–0.812	0.010
CD3CD8CD45ROd	0.271	0.118–0.624	0.002	0.282	0.121–0.658	0.003

CI=confidence interval; HR=hazard ratio.

The results were according to the density groups of TIL with 75th percentile cutoffs.

Univariate and multivariate Cox proportional hazards models were used as statistical methods.

^aTumour stage (T stage), histologic classification (WHO), presence of lymph node metastasis, and presence of lymphatic invasion which were proved to have prognostic significance in univariate analysis were adopted as covariates in each multivariate analysis.

^bHigh vs low.

^cHigh/high vs low/low.

^dHigh/high/high vs low/low/low.