Table 2. Association of protein marker expression and 5-year cancer-specific survival time in patients with rectal cancer (univariate analysis; Cox proportional hazards regression).
| Protein marker | Cutoff score | Negative N (%) | Positive N (%) | HR (95% CI) | P-value |
|---|---|---|---|---|---|
| APAF-1 | 90% | 226 (53.2) | 199 (46.8) | 0.98 (0.74–1.29) | 0.876 |
| EphB2 | 70% | 150 (39.8) | 227 (60.2) | 0.92 (0.66–1.27) | 0.549 |
| Ki67 | 15% | 221 (57.6) | 163 (42.5) | 0.72 (0.53–0.97) | 0.033 |
| MST1 | 70% | 124 (31.2) | 274 (68.8) | 0.76 (0.56–1.02) | 0.068 |
| p53 | 20% | 199 (46.9) | 225 (53.1) | 1.08 (0.82–1.42) | 0.584 |
| RHAMM | 90% | 239 (59.3) | 164 (40.7) | 2.19 (1.65–2.91) | <0.001 |
| RKIP | 80% | 128 (34.5) | 243 (65.5) | 0.69 (0.51–0.93) | 0.015 |
| CD8+ TILs | four cells/HPF | 275 (60.0) | 183 (40.0) | 0.55 (0.41–0.74) | <0.001 |
HPF=high-power field; HR=hazard ratios; CI=confidence interval.