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. 2008 Oct 28;99(10):1718–1725. doi: 10.1038/sj.bjc.6604747

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Copyright © 2008 Cancer Research UK

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(A) OS (overall survival) and (B) DFS (disease-free survival) Kaplan–Meier survival plots according to PRL-3 expression status. Eighty primary metastatic colorectal tumours (46 stage IIIB and 34 stage IIIC) and their correspondent normal colonic mucosa were obtained from the Department of Pathology of the Hospital Universitari de Bellvitge. Among the 80 CRCs, we classify 43 CRC (29 stage IIIB and 14 stage IIIC) that did not develop distant metastases for at least 60 months and 37 CRCs (17 stage IIIB and 20 stage IIIC) that developed liver or/and lung metastases. All patients underwent surgical resection – 70 radical surgery and 10 palliative surgery. All patients received adjuvant chemotherapy treatment. The median follow-up was 107.30 months (range: 43–132). End points were local recurrence for DFS and cancer-related death or last follow-up for OS. At the end of the follow-up period 45out of 80 patients (56.25%) were alive without disease, six (7.5%) were alive with disease and 29 died of cancer. PRL-3 expression values were normalised for β2-microglobulin. Absolute expression of each tumour sample was adjusted for expression of its paired normal colonic mucosa. P-values correspond to the univariate model of Cox regression test and were considered significant if P⩽0.05.