TABLE 1.

Model Parameters

Parameter	Description	Value	Reference
a	Maximum T-cell proliferation rate	0.09 (d−1)	9
aL	Latent (memory) cell activation	0.01 (d−1)	54
Amax	Pathogen carrying capacity	108 (cells/mL/d)	9
αL	Fraction latently infected	0.001	40
c	Virion clearance rate	23 (d−1)	55
d0	Death rate, quiescent cells	0.01 (d−1)	54
d	Death rate, division classes	0.1 (d−1)	9
dLA	Death rate, antigen specific	0.325 (d−1)	56
dE	Death rate, effector cells	0.325 (d−1)	56
dT	Death rate, nonspecific	0.01 (d−1)	54
δ′	Density-dependent mortality	0.7863 d−1 (mL·cell−1)ω	57
μ′	Density-dependent mortality	0.07863 d−1 (mL·cell−1)ω	57
εRT	Drug efficacy	0 < εRT < 1	Appendix
εPI	Drug efficacy	0 < εPI < 1	Appendix
f	Reduction in drug efficacy	0 < f ≤ 1
γ	Pathogen clearance rate	10−3 (d−1)	9
k1	Infectivity, primary pool	8 × 10−7 (mL/d−1)	57
k2	Infectivity, secondary pool	1 × 10−4 (mL/d−1)	57
K4, K8	Antigen half-saturation	1000	9
λ1	Primary T-cell source	104 (cells/mL/d−1)	57
λ2	Secondary T-cell source	99, 57, 43 (cells/mL/d−1)
N0	Initial quiescent population	500 cells/mL	9
p0	Initial proliferation rate	1 ( d −1)	54
p	Proliferation rate, classes 1, .., k	2.92 (d−1)	54
ω	See Appendix	0.01	57
q1, q2	Viral production rates	70, 0.28 (d−1)	57, 58
r0	Maximum pathogen growth rate	2 ( d −1)	9
ρ	Rate of reversion to memory	0.01 (d−1)	54