Fig. 2.

Functional gap junctions and channels are formed by rat insulinoma (Rin) cells induced to express Cx37 (iRin37). A: mean conductance and individual data points for junctions formed by pairs of iRin37-F and -H cells. Means were not different despite different expression levels (see supplemental data Fig. 1S). Data for iRin37-F clone were derived from 7 different cultures on 7 distinct days, and data for iRin37-H were from 2 different cultures and days. Multiple coverslips of cells were used each day. B: single-channel record and all points histogram from a pair of iRin 37-F cells. Conductance of the fully open channel was ∼350 pS, and at least two substates (100 and 180 pS) were observed.