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Schematic representation of GR trafficking: Upon binding glucagon (G), the GR is internalized. After short-term stimulation with glucagon, the GR recycles to the plasma membrane through Rab4- and Rab11-positive vesicles in a β-arrestin (AR)-dependent manner. Prolonged stimulation directs GR to degradation in lysosomes (LY) and possibly proteosomes (PS). RV, recycling vesicle; RE, recycling endosome; Chlor, chloroquine; LE, late endosome.
