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. 2008 Sep 11;295(5):C1292–C1301. doi: 10.1152/ajpcell.00230.2008

Fig. 1.

Fig. 1.

Effect of vascular endothelial growth factor (VEGF) on the cytochrome P-450 (CYP) CYP2C gene in endothelial cells. A: CYP2C9 promoter activity in porcine endothelial cells overexpressing VEGFR1 or VEGFR2 were transfected with the promoter construct 14 h before stimulation with VEGF (30 ng/ml, 6 h). B: time course showing the effect of VEGF (30 ng/ml, 3–48 h) on the expression of CYP2C mRNA in human umbilical vein endothelial cells. Bar graphs summarize data obtained in 7–13 independent experiments. *P < 0.05, ***P < 0.001 vs. control (CTL).