Fig. 2.

Effect of VEGF on the expression and activity of CYP2C in endothelial cells. A: time course showing the effect of VEGF (30 ng/ml, 6–48 h) on the expression of CYP2C protein. CYP2C8-containing bacterial supersomes were used as a positive control (pc). B: 11,12-epoxyeicosatrienoic acid (EET) production in human umbilical vein endothelial cells. Some experiments were performed in the presence of miconazole (Mic, 3 μmol/l). Bar graphs summarize data obtained in 3–10 independent experiments. *P < 0.05, **P < 0.01 vs. control (CTL).