Infarct size in wild-type and TNFR-deficient mice. Infarct size was determined in wild-type TNFR mice (n = 8), TNFR1/TNFR2-deficient mice (n = 5), TNFR1-deficient mice (n = 6), and TNFR2-deficient mice (n = 6). (see Methods for details) and then expressed as a percentage of the total area of the LV myocardium that was at risk (see Methods for details). ∗ = P < 0.01 compared with control values. R1/R2 KO, TNFR1/TNFR2-deficient mice; R1 KO, TNFR1-deficient mice; and R2 KO, TNFR2-deficient mice.