Fig. 1.
A: cadmium sensitivity of Chinese hamster ovary (CHO)-K1 wild-type (WT) and metallothionein (MT)-1 transfectants determined by clonogenic survival. Data are mean values derived from triplicate determinations. B: immunoblot for MT-1 protein expression using a mouse monoclonal antibody E9 to isoforms I and II. C: CHO-K1 MT-1 2.20.1 transfectant and WT both show rapid and complete growth inhibition at 500 μM Zn2+. D: CHO-K1 MT-1 transfectants show enhanced resistance to Zn2+ toxicity. Data are mean values (± SD) derived from 3 experiments.