Table 2. Mutations in p16/CDKN2a detected in patients with Barrett's esophagus.

Alteration*	Diagnosis	p14ARF status	Percent of BE segment
172C>Td	HGD	Pro to Leu	29
172C>T	Metaplasia	Pro to Leu	50
172C>T	HGD	Pro to Leu	43
172C>T	IND/LGD	Pro to Leu	67
172C>T	HGD	Pro to Leu	33
172C>T	HGD	Pro to Leu	100
172C>Ta , d	HGD	Pro to Leu	No data
172C>Tb	HGD	Pro to Leu	33
174_175del2	IND/LGD	Frameshift	100
175_221del47	IND/LGD	Frameshift	25
179C>A	IND/LGD	No alteration	100
179_183dup5	IND/LGD	Frameshift	100
182_283del102	Metaplasia	deletion	100
181G>T	Metaplasia	Gly to Val	67
191_205del15	HGD	deletion	100
198_343del146	IND/LGD	deletion/frameshift	100
202G>A	IND/LGD	Arg to His	50
220G>A	IND/LGD	Arg to Gln	75
233_234del2c	IND/LGD	Frameshift	43
235_245del11	IND/LGD	Frameshift	100
238C>T	Metaplasia	Pro to Leu	100
238C>Td	HGD	Pro to Leu	50
238C>T	IND/LGD	Pro to Leu	40
238C>T	Metaplasia	Pro to Leu	100
238C>T	IND/LGD	Pro to Leu	100
238C>T	IND/LGD	Pro to Leu	33
238C>T	IND/LGD	Pro to Leu	17
238C>T	IND/LGD	Pro to Leu	17
238C>T	IND/LGD	Pro to Leu	100
238C>T	IND/LGD	Pro to Leu	100
238C>T	IND/LGD	Pro to Leu	50
238_254del17	IND/LGD	Frameshift	100
238C>T	IND/LGD	Pro to Leu	100
238C>T	HGD	Pro to Leu	25
247C>Tc	IND/LGD	Ala to Val	14
247C>T	IND/LGD	Ala to Val	50
247C>T	HGD	Ala to Val	100
247C>T	IND/LGD	Ala to Val	80
247C>T	IND/LGD	Ala to Val	25
247C>T	HGD	Ala to Val	100
262G>T	IND/LGD	Gly to Val	100
262G>T	IND/LGD	Gly to Val	25
289delCd	HGD	Frameshift	33
290 T>Cb	HGD	No alteration	33
330 G>A	IND/LGD	Gly to Arg	100
323_341dup19	IND/LGD	Frameshift	50
387C>Aa , d	HGD	Pro to Thr	100

^a,b,cindicates three patients each having two distinct alterations found at different levels in the esophagus.

^dindicates mutation that was also found in esophagectomy specimen from the same patient.

^*Reference sequence used was NM_000077; nucleotide numbering is as found in The CDKN2A Database[4]. Diagnosis is at baseline endoscopy.

^**Indicates the percentage of the esophagus having Barrett's epithelium that contained the mutation.