TABLE 19.
Agent | Trade name | Strengths available (mg) | Start dose (range) | Route of administration | Listed indications |
---|---|---|---|---|---|
Nabilone | Cesamet* | 0.5, 1 | 0.5 mg/hs (1–2 mg bid) | Oral | Antiemetic in cancer chemotherapy |
Synthetic Δ-9-THC | Marinol† | 2.5, 5, 10 | 5 mg (5–10 mg bid) | Oral | Antiemetic in cancer chemotherapy |
Extract of naturally occurring Δ-9-THC and CBD | Sativex‡§ | 2.7 Δ-9-THC/2.5 CBD** | –¶ | Transbuccal | Adjunctive treatment for pain in multiple sclerosis |
Valeant Canada Ltd;
Solvay Pharma Inc, Canada;
GW Pharma Ltd, United Kingdom;
Approved under a conditional notice of compliance by Health Canada as of April 2005;
Insufficient published information to make recommendations regarding dose at the time of writing;
Each spray contains 2.7 mg delta-9-tetrahydro-cannabinol (Δ-9-THC) and 2.5 mg cannabidiol (CBD). bid Twice a day; hs At bedtime