Table 2.
Results of single dose trials in dental and postsurgical pain for comparison of dexketoprofen with placebo, and dexketoprofen with ketoprofen
| Dexketoprofen versus placebo | ||||||
| Number of | Percent of patients with at least 50% pain relief | |||||
| Dexketoprofen dose (mg) | Trials | Patients | Dexketoprofen | Placebo | Relative benefit (95% CI) | NNT (95% CI) |
| All trials | ||||||
| 10/12.5 mg | 5 | 462 | 45 | 17 | 3.4 (2.2 to 5.6) | 3.5 (2.7 to 4.9) |
| 20/25 mg | 5 | 455 | 50 | 17 | 3.9 (2.4 to 6.3) | 3.0 (2.4 to 3.9) |
| 50 mg | 1 | 67 | 56 | 8 | 6.7 (1.7 to 26) | 2.1 (1.5 to 3.5) |
| Dental | ||||||
| 10/12.5 mg | 3 | 261 | 47 | 13 | 3.5 (2.2 to 5.6) | 3.0 (2.3 to 4.4) |
| 20/25 mg | 3 | 254 | 52 | 13 | 3.9 (2.4 to 6.3) | 2.6 (2.0 to 3.5) |
| 50 mg | 1 | 67 | 56 | 8 | 6.7 (1.7 to 26) | 2.1 (1.5 to 3.5) |
| Postsurgical | ||||||
| 10/12.5 mg | 2 | 201 | 43 | 21 | 2.1 (1.4 to 3.3) | 4.4 (2.8 to 9.7) |
| 20/25 mg | 2 | 201 | 47 | 21 | 2.3 (1.5 to 3.6) | 3.7 (2.5 to 7.0) |
| Dexketoprofen versus ketoprofen | ||||||
| Number of | Percent of patients with at least 50% pain relief | |||||
| Dexketoprofen/ketoprofen dose (mg) | Trials | Patients | Dexketoprofen | Ketoprofen | Relative benefit (95% CI) | NNT (95% CI) |
| All trials | ||||||
| 12.5 vs 50 | 3 | 287 | 44 | 35 | 0.8 (0.5 to 1.2) | not calculated |
| 25 vs 50 | 3 | 284 | 51 | 35 | 1.1 (0.7 to 1.5) | not calculated |
| 50 vs 100 | 1 | 247 | 82 | 77 | 1.1 (0.9 to 1.2) | not calculated |
| 25/50 vs 50/100 | 4 | 531 | 65 | 54 | 1.2 (1.1 to 1.4) | 8.8 (5.1 to 33) |