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Protection of transgenic HLA-DQ8 mice from Streptococcus pyogenes sepsis following vaccination with SpeA (L42R)-SpeB (C47S) fusion protein. Mice (5 per group) were vaccinated three times with 10 μg of each protein with adjuvant (MPL), allowing two weeks between injections. Three weeks after the last vaccination the mice were injected (i.v) with 10 LD50 of S. pyogenes and survival was monitored for 10 days.
