Table 3.

Replications of genotypic combinations analyses on stratifications of the patients and controls groups determined according to geographical origin and/or age.

	Individuals originating from Vendée				Individuals ≤ 67 years				Individuals from Vendée ≤ 67 years
Genotypic combinations patterns	Controls (n = 189)	Cases (n = 420)	OR (95% CI)	p*	Controls (n = 768)	Cases (n = 529)	OR (95% CI)	p*	Controls (n = 134)	Cases (n = 232)	OR (95% CI)	p*
Reference pattern	14	29	1.00		65	31	1.00		12	16	1.00
Mixed patterns	171	359	0.92 (0.47–1.83)		676	460	1.42 (0.91–2.21)		120	195	1.15 (0.52–2.56)
Predisposing patterns	4	32	3.80 (1.10–13.19)	0.011	27	38	3.00 (1.56–5.77)	0.003	2	21	7.22 (1.38–37.80)	0.009
Reference and mixed patterns	185	388	1.00		741	491	1.00		132	211	1.00
Predisposing patterns	4	32	4.14 (1.42–12.08)	0.002	27	38	2.17 (1.31–3.61)	0.003	2	21	6.36 (1.44–28.09)	0.002

OR calculations were all adjusted by age and sex.