Fig. 3.

Rejection or delayed tumor growth by adoptive transfer of T cells into an MHC-deficient environment. a Groups of B6 mice were treated with saline (unchallenged) or with 5 × 10⁵ unmodified LL cells (AE-NR) as in Fig. 1. After 16 days, mice were sacrificed and T cells were purified from the spleen and draining lymph nodes. SCID mice or DKO mice then received saline injections or were adoptively transferred (AT) with pooled unchallenged or antigen-experienced T cells as indicated in the legends. Two weeks later, mice were injected with 5 × 10⁵ LL cells subcutaneously in the flank. Tumor growth was monitored by palpation. Data show the proportion of tumor-free mice followed for 60 days. b Mice (groups of 8–12 for WT and groups of 5–11 for DKO) were followed for the first 18 days as in Fig. 2. Tumor burden (in mm³) was determined by measuring two diameters