Organ weights/body weight expressed as percentage of WT mice at 4 months of age in WT, ERKO, BERKO, and DERKO (n = 6 for WT; n = 9 for ERKO; n = 5 for BERKO; and n = 5 for DERKO). Values are given as means ± SEM. Data were first analyzed by a one-way ANOVA, followed by Student–Newman–Keuls multiple range test. *, P < 0.05 versus WT.