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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Neurochem. 2008 Sep 15;107(4):1001–1013. doi: 10.1111/j.1471-4159.2008.05685.x

Fig. 9.

Fig. 9

A model to show the action of ethanol on excitatory neurotransmission involving ECs and CB1 receptors. The action of ethanol causes the generation of ECs (AEA and 2-AG). These ECs then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of glutamate by inhibiting N-type and P/Q-type calcium channels (Hoffman & Lupica 2000, Huang et al. 2001, Shen & Thayer 1998). GluR, glutamate receptors.