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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Hepatol. 2008 May 22;49(2):251–261. doi: 10.1016/j.jhep.2008.04.015

Figure 9. Effect of ECM on bile acid induced phosphorylation of p38 MAPK.

Figure 9

Hepatocytes were plated on Type 1 collagen (I), laminin (LM) or polylysine (PL) and the amount of p38 MAPK phosphorylation determined by immunoblotting 6 hours later. Representative immunoblots are shown in A and B is the quantification (mean and standard deviation) of 3 separate experiments. C. Hepatocyte adhered to I, LM or PL were treated with 50 uM glycochenodeoxycholate (GCDC) for 2 hrs +/− 15 minute pretreatment with 5 uM SB 203580 and the amount of apoptosis determined morphologically by evaluation of Hoechst stained cells. The results are the mean and standard deviation of 3 separate experiments.