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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Evolution. 2008 Aug 26;62(11):2884–2893. doi: 10.1111/j.1558-5646.2008.00483.x

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Dynamic regulation of isoforms can increase phenotypic robustness. Contour fitness landscape of systems without (A) and with (B) isoforms. Regions with same shading have equal fitness. Fitness has a maximum value of 1 (white regions) when the system has a period of 24 hours. Darker regions indicate parameter combinations that give periods that deviate from 24 hours. In panel B, K11P=0.5 and K12P=5 and for each combination of k1 and kSP α is adjusted to produce, if possible, a circadian period.