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Operant responding for dihydrotestosterone (DHT), estradiol (E2) or their combination (DHT+E2) in male hamsters (mean±SEM). During daily 4-h test sessions, hamsters acquire a significant preference for the active nose-poke (closed bars) over the inactive nose-poke (open bars) when self-administering either DHT, E2, or DHT+E2 icv, but not during self-administration of oxymetholone or stanozolol. Asterisks indicate significant preference for the active nose-poke. Redrawn from [51].
