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Deficit in local excitation of FS neurons persists in adolescent Fmr1 KO mice. A: examples of unitary EPSCs targeting layer 4 FS neurons in slices obtained from 4-wk-old animals. Only 1st 4 EPSCs shown. Scale bars: 1,000 and 20 pA, 50 ms. B: no change in connection frequency. C–E: EPSC1 amplitude and drive are decreased while short-term plasticity (F, n = 33,26) is unchanged. *P < 0.04.
