FIG. 8.

Synchrony of UP states is decreased in Fmr1 KO mice. A: UP states occurring in 2 simultaneously recorded excitatory neurons observed at +10 mV. Scale bars: 500 pA, 250 ms. B: the traces in A are filtered with a 20- to 100-Hz band-pass filter and the 1st 400 ms of the UP states from each cell are superimposed (black and red refer to top and bottom traces, respectively). Scale bars: 200 pA, 100 ms. C: cross-correlograms for the traces in B. D: an average correlogram peak is calculated for each cell pair and plotted against intercellular distance. E: data in D are averaged and reveal a 13% decrease in UP state synchrony in Fmr1 KO slices. *P < 0.004.