*Table 2.
Correlation of BChE Activity and the ACE Model
| A. | MZF | MZM | DZF | DZM | DZOS |
|---|---|---|---|---|---|
| N of pairs | 408 | 158 | 224 | 77 | 217 |
| Correlation of plasma cholinesterase activity | 0.73 | 0.65 | 0.40 | 0.44 | 0.43 |
| B. | Percentage of variance due to: | |||||||
|---|---|---|---|---|---|---|---|---|
| Models | −2LL | df | Δχ2 | Δdf | p | A | C | E |
| 65 | 7 | 28 | ||||||
| ACE | 7922.5 | 2157 | - | - | - | (50–75) | (0–21) | (25–32) |
| AE | 7923.5 | 2158 | 1.01 | 1 | 0.315 | 72 | - | 28 |
| CE | 8007.6 | 2158 | 85.2 | 1 | <10−18 | - | 58 | 42 |
MZF = monozygotic female
DZF = dizygotic female
LL = log likelihood
MZM = monozygotic male
DZM = dizygotic male
df = degrees of freedom
DZOS = dizygotic other sex
A. Pairwise similarity of twin plasma cholinesterase results, by zygosity, after adjustment for method variation, sex and sex-specific age effects.
B. Results of fitting the data to models containing sources of variation due to: A, additive genetic effects, C, shared-environmental effects, and E, non-shared environmental effects. The 95% confidence intervals for estimates of A, C and E under the ACE model are also shown. Comparison of the goodness-of-fit between the data and the models shows that the AE model is not significantly worse than the full ACE model, but that the CE models is strongly rejected.
Valle, A., et al., Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity. Clin Chem, 2006. 52(6): p.1014-20.