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. 2008 Dec 3;3(12):e3858. doi: 10.1371/journal.pone.0003858

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Pi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) Comparison of the lean body mass (A), fat content (B) and bone mineral density of the femur analysis (C) by PIXImus^TM analysis in GPRC6A ^+/+ and GPRC6A ^−/− mice at ages ranging from 6 to 16 weeks. Data represent the mean±SEM from 6 to 10 mice in each group. * Significant difference from GPRC6A^+/+ and GPRC6A ^−/− mice at p<0.05. (D) Backscattered Scanning Electron Microscopy analysis of tibia cortical bone in 16-week-old GPRC6A^+/+ (upper panel) and GPRC6A ^−/− mice (lower panel). The arrows showed the diminished mineralization layer in the bone of GPRC6A ^−/− mice. (E) Toluidine blue-stained plastic sections of femur from 16-week-old GPRC6A^+/+ (upper panel) and GPRC6A ^−/− mice (lower panel). The arrows showed the unmineralized osteoid surfaces in the bone of GPRC6A ^−/− mice. (F) Plastic unstained sections of tibia cortical bone viewed under fluorescent light in 16-week-old GPRC6A^+/+ (upper panel) and GPRC6A ^−/− mice (lower panel) prelabeled with twice calcein (double label).