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Decreased clonogenic survival after IR in ATM-deficient cells but not c-Abl−/− p53−/− cells. Embryo fibroblast cells of defined genotypes as indicated were given graded doses of IR, and clonogenic survival is shown as a fraction of unirradiated control. Data are representative of two (p53−/− ATM−/−) or three (p53−/− and c-Abl−/− p53−/−) independent experiments.
