Figure FIG. 7.

Transplantation of BMSCs in vivo. BMSCs derived from FD lesions and normal sites were combined with HA/TCP as a carrier (C) and transplanted subcutaneously into immunocompromised mice. (A) BMSCs from lesions with high levels of mutation (patient 1) reproduced a fibrous dysplastic ossicle characterized by formation of poorly mineralized woven bone (WB) and fibrous tissue (FT), reminiscent of a native lesion. (B) BMSCs from lesions in which the level of mutation was only detectable by PNA‐inhibited amplification (patient 10, sample b) formed normal lamellar bone (LB) and established a normal hematopoietic marrow (HP). (C) BMSCs derived from a normal site, but mutation positive by the PNA assay (patient 16, sample a) also established a normal ossicle.