Table 2.

Analysis of gene effects by ethnicity (regression-based tests)

ethnicity	variant	reference allele	HTN status	SBP		phenotype r2	SBP - asb regressed		DBP		phenotype r2	DBP - asb regressed
			P-value	P-value	eff. size [mmHg]		P-value	eff. size [mmHg]	P-value	eff. size [mmHg]		P-value	eff. size [mmHg]
AA						0.87					0.92
	rs2398162	A	0.400	0.668	-8.3		0.477	-11.1	1.000	-0.7		1.000	-0.4
	rs2820037	A	0.180	0.337	10.1		0.631	4.0	0.668	-1.4		0.668	-1.2
	rs6997709	G	0.740	0.439	10.4		0.710	3.8	1.000	-0.6		1.000	-0.1
	rs7961152	C	0.340	0.520	6.9		0.439	6.8	0.240	4.1		0.283	3.1
	rs11110912	C	0.660	0.830	-3.0		0.477	-15.0	0.710	-1.8		0.830	-1.3
	rs1937506	G	0.550	0.830	-1.6		0.762	-3.3	0.830	0.9		0.762	1.0
EA						0.77					0.77
	rs2398162	A	0.640	0.265	-13.2		0.218	-11.5	0.570	2.0		0.762	0.9
	rs2820037	A	0.830	0.057	27.3		0.108	17.2	0.020	9.8		0.086	6.2
	rs6997709	G	0.670	0.520	-6.3		0.406	-7.8	0.439	-2.6		0.337	-2.7
	rs7961152	C	0.440	0.198	-12.3		0.830	-1.6	0.044	-6.1		0.081	-4.4
	rs11110912	C	0.910	0.762	6.2		0.762	-3.2	0.477	3.0		0.668	1.4
	rs1937506	G	0.600	0.032	-26.8		0.009	-24.9	0.077	-6.2		0.004	-8.7
HA						0.72					0.85
	rs2398162	A	0.068	0.159	22.7		0.211	-13.4	0.350	3.3		0.710	-1.2
	rs2820037	A	0.300	0.497	16.1		0.422	12.9	0.089	8.9		0.159	6.3
	rs6997709	G	0.320	1.000	3.5		0.077	24.4	0.710	1.6		0.599	2.0
	rs7961152	C	0.060	0.406	-14.1		0.256	13.2	0.325	3.6		0.477	2.3
	rs11110912	C	0.420	0.668	-9.4		0.439	13.6	0.497	-3.8		0.599	-2.5
	rs1937506	G	0.060	0.005	49.9		0.024	27.7	0.325	4.0		0.164	4.9

MERLIN 1.1-alpha (association option) was used for this analysis.

SBP: systolic blood pressure

DBP: diastolic blood pressure

asb regressed: regressed on age, sex, and bmi

AA: African Americans; EA: European Americans; HA: Hispanic Americans

phenotype r²: correlation between the phenotype to the left and right (asb regressed)

P-values were not adjusted for multiple testing.

An additive model was assumed for all analyses.

P-value <0.05

P-value <0.01