Fig. 7.

(1) Molaee-Ardekani et al. (2007) simulated EEG (mean soma membrane potential h _e) at various concentrations of simulated anaesthesia by assuming that anaesthetics, in addition to increasing the duration of the IPSP, also cause slow adaptive changes in the shape of the mesoscopic firing rate function which relates mean soma membrane potential to mean population firing rate. (2) Actual EEG recorded in children undergoing anaesthesia with the volatile halogenated agent desflurane. (a) 0 MAC (minimum alveolar concentration), (b) 1 MAC, (c) > 1 MAC and (d) 2 MAC. Both real and simulated data show that increasing anaesthetic effect is associated with enhanced total EEG power and reductions in mean frequency. Figure adapted from Figs. 6 and 9 of Molaee-Ardekani et al. (2007), with permission