Fig. 8.

Liley and Bojak (2005) showed that systematically modulating IPSP shape and amplitude could induce high firing large amplitude activity in a mean field model parameterised to produce electroencephalographically plausible activity (‘1/f’ low frequency activity and strong alpha resonance). (a) spectra of model EEG activity associated with physiologically plausible parameterisations (b) It is predicted that anaesthetics that more rapidly reduce the amplitude of the IPSP (Γ_ik) in addition to prolonging it (ζ_ik), are more likely to produce high firing large amplitude activity electroencephalographic characteristic of epileptiform activity. This may explain why the volatile agent enflurane is paradoxically pro-convulsant. Figure adapted from Figs. 5 and 11 of Liley and Bojak (2005)