Figure 4. GSK3 inhibition results in up-regulation of Death Receptors and TRAIL.
Western blot of total U251 cell lysates shows that DR4 and DR5 are up-regulated with (A) GSK3 inhibitors as indicated (all at a 0.5 μM concentration for 24 hours of treatment) (B) and by GSK3 siRNAs. (C) TRAIL is up-regulated by GSK3siRNA (48 hours of treatment).