Figure 6. GSK3 inhibition potentiates the anti-tumor action of other cytotoxic drugs in vitro and in vivo.
(A) TRAIL acts synergistically with enzastaurin in glioma cell killing. (B) Overexpression of c-MYC kills glioma cells. TRAIL enhances cell death caused by c-MYC overexpression. (C) Combination of enzastaurin with carboplatin results in significantly reduced tumor volume in a mouse subcutaneous U87 xenograft model. (D) Combination of enzastaurin with carboplatin prolongs survival in U87 intracranial xenograft model.